Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae

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Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.

The Nonsense-Mediated mRNA Decay (NMD) pathway mediates the rapid degradation of mRNAs that contain premature stop mutations in eukaryotic organisms. It was recently shown that mutations in three yeast genes that encode proteins involved in the NMD process, UPF1, UPF2, and UPF3, also reduce the efficiency of translation termination. In the current study, we compared the efficiency of translatio...

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Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in <i>S. cerevisiae</i>

The Nonsense-Mediated mRNA Decay (NMD) pathway mediates the rapid degradation of mRNAs that contain premature stop mutations in eukaryotic organisms. It was recently shown that mutations in three yeast genes that encode proteins involved in the NMD process, UPF1, UPF2, and UPF3, also reduce the efficiency of translation termination. In the current study, we compared the efficiency of translatio...

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ژورنال

عنوان ژورنال: RNA

سال: 2004

ISSN: 1355-8382

DOI: 10.1261/rna.5147804